The drug is an immunosuppressive agent. Sirolimus is a macrocyclic lactone produced by Streptomyces hygroscopicus. It is also commonly known as Rapamycin or Rapamune. It is used to prevent organ rejection (kidney transplants) but is also being used in clinical trials in combinations for the treatment of various cancers.
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Sorafenib is a multikinase inhibitor targeting several serine/threonine and receptor tyrosine kinases. The drug is marketed as Nexavar and is used in the treatment of renal cell carcinoma (Kidney cancer). It is also being studied as treatment in other types of cancer.
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Sunitinib is used as a targeted therapy and a receptor protein-tyrosine kinase inhibitor for advanced renal cell cancer and gastrointensinal stromal tumor (GIST). Sunitinib is marketed under the name Sutent. The drug may also be used in combination with other chemotherapy drugs or for the treatment of other cancers.
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