The prefecture of Serres is a part of the geographical district of Eastern Macedonia, and it borders with Bulgary and F.Y.R.O.M. in the north, the prefecture of Drama in the east, the prefecture of Kavala on the southeastern, the prefecture of Thessaloniki and the prefecture of Kilkis in the west. It has approximately 193.000 inhabitants.

Serres, the capital of the prefecture, is a modern town and the commercial center of the greater region. However, it remains an interesting destination as it pulses with archaeological sites, scenic churches and monasteries, traditional villages, museums, natural sites and the ski center Vrontous.