Easthampton is a city located in Hampshire County, Massachusetts.

It was first settled by European immigrants beginning in 1664 and was originally considered part of Northampton. In 1785, the village of Easthampton was formally named its own separate political entity, and twenty-four years later, it officially became a town and could be represented in the House.

The town grew primarily around the Manhan River, both through its phase as a strictly agricultural community and later, through the industrial revolution, when mills and factories were first built in Easthampton, mainly in connection with textile manufacturing and its offshoots.